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Effect of Hepatic or Renal Impairment on Eltrombopag Pharmacokinetics
Author(s) -
Bauman John W.,
Vincent Carolyn T.,
Peng Bin,
Wire Mary B.,
Williams Daphne D.,
Park Jung Wook
Publication year - 2011
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270010372106
Subject(s) - eltrombopag , medicine , pharmacokinetics , regimen , nausea , adverse effect , thrombopoietin receptor , gastroenterology , pharmacology , platelet , thrombopoietin , genetics , stem cell , haematopoiesis , biology , immune thrombocytopenia
Eltrombopag, an oral, small‐molecule, nonpeptide thrombopoietin receptor agonist for the treatment of thrombocytopenia, is highly protein bound and primarily eliminated via metabolism in the liver and gastrointestinal tract. Single‐dose eltrombopag pharmacokinetics were evaluated in participants with hepatic or renal impairment given possible changes in systemic exposure due to reduced plasma protein binding or reduced metabolism. All participants received a single 50‐mg dose of eltrombopag. The adverse event profile was similar across groups, with headache, nausea, and back pain most frequently reported. Compared with healthy participants, participants with mild, moderate, or severe hepatic impairment had mean increases in AUC 0‐∞ of 41%, 93%, and 80%, and participants with mild, moderate, or severe renal impairment had mean decreases in AUC 0‐∞ of 32%, 36%, and 60%. There was high pharmacokinetic variability and significant overlap in exposures between participants with hepatic or renal impairment and healthy participants. Results suggest that patients with renal impairment may initiate eltrombopag with the standard 50‐mg once‐daily starting regimen, whereas patients with moderate or severe hepatic impairment should consider a lower 25‐mg once‐daily regimen. Patients with hepatic or renal impairment should be closely monitored for platelet response and safety, and eltrombopag doses should be adjusted accordingly.