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Effects of Commonly Administered Agents and Genetics on Nebivolol Pharmacokinetics: Drug‐Drug Interaction Studies
Author(s) -
Lindamood Charles,
Ortiz Stephan,
Shaw Andrew,
Rackley Russ,
Gorski J. Christopher
Publication year - 2011
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270010370846
Subject(s) - nebivolol , pharmacology , drug interaction , cyp2d6 , medicine , cyp2c9 , drug , pharmacokinetics , debrisoquine , hydrochlorothiazide , pharmacogenetics , digoxin , cytochrome p450 , heart failure , chemistry , genotype , blood pressure , biochemistry , metabolism , gene
Drug interactions are a significant clinical concern, particularly in patients with conditions such as heart disease and hypertension, in whom coadministration of multiple drugs is common. Nebivolol is a selective β 1 ‐blocker with vasodilatory properties approved for the treatment of hypertension. Drug‐drug interactions were investigated when nebivolol was coadministered to subjects classified as poor CYP2D6 metabolizers and extensive CYP2D6 metabolizers who were receiving other drugs commonly administered to patients with hypertension or compounds metabolized by cytochrome P450 (CYP) 2D6. There were no drug‐drug interactions when nebivolol was coadministered with hydrochlorothiazide, furosemide, ramipril, losartan, digoxin, or warfarin. Coadministration with fluoxetine (also metabolized by CYP2D6) in extensive CYP2D6 metabolizers impeded the apparent clearance of nebivolol. The authors conclude that nebivolol is safe and well tolerated regardless of genotype and type of medication coadministered.