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Modeling of 24‐Hour Glucose and Insulin Profiles of Patients With Type 2 Diabetes
Author(s) -
Jauslin Petra M.,
Frey Nicolas,
Karlsson Mats O.
Publication year - 2011
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270010362536
Subject(s) - insulin , context (archaeology) , endocrinology , medicine , circadian rhythm , diabetes mellitus , type 2 diabetes , glucose homeostasis , insulin resistance , biology , paleontology
A model able to simultaneously characterize and simulate 24‐hour glucose and insulin profiles following multiple meal tests was developed, extending an integrated glucose‐insulin model for oral glucose tolerance tests that was previously published. The analysis was based on glucose and insulin measurements from 59 placebo‐treated patients with type 2 diabetes. Circadian variations in glucose homeostasis were assessed on relevant parameters based on literature review. They were best described by a nighttime dip in insulin secretion between approximately 9 p.m. and 5 a.m. using a modulator function. The integrated glucose‐insulin model has thus been shown to be applicable to real‐life situations determined by multiple meals over the course of a day. This provides the basis for the analysis and simulation of long‐term glucose and insulin data. The model may also prove useful for understanding antidiabetic drug actions and requirements in the context of circadian changes in glucose‐insulin regulation.