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Hypersensitivity Syndrome Induced by Anticonvulsants: Possible Cross‐Reactivity Between Carbamazepine and Lamotrigine
Author(s) -
Aouam Karim,
Romdhane Foued Ben,
Loussaief Chaouki,
Salem Randa,
Toumi Adnène,
Belhadjali Hichem,
Chaabane Amel,
Boughattas Naceur A.,
Chakroun Mohamed
Publication year - 2009
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270009344985
Subject(s) - lamotrigine , carbamazepine , interstitial pneumonitis , medicine , patch test , eosinophilia , anesthesia , gastroenterology , anticonvulsant , rash , pharmacology , epilepsy , immunology , allergy , lung , respiratory disease , psychiatry
A 14‐year‐old male presents with erythroderma and fever 44 days after carbamazepine intake. Laboratory exams show eosinophilia and elevated liver enzymes, and thoracic imaging reveals interstitial pneumonitis. All symptoms disappear after carbamazepine withdrawal. A patch test to carbamazepine performed 6 weeks after recovery is positive. About 8 months later, the patient exhibits the same clinical and biological picture 52 days after lamotrigine intake. Lamotrigine is stopped and all symptoms disappear. A patch test to LMG is positive. This case illustrates a possible cross‐reactivity between carbamazepine and lamotrigine, which are aromatic and nonaromatic anticonvulsants, respectively.