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Effect of Thyroid Hormone on the Activity of CYP3A Enzyme in Humans
Author(s) -
Takahashi Norio,
Inui Naoki,
Morita Hiroshi,
Takeuchi Kazuhiko,
Uchida Shinya,
Watanabe Hiroshi,
Nakamura Hirotoshi
Publication year - 2010
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270009344336
Subject(s) - cyp3a , endocrinology , triiodothyronine , medicine , hormone , thyroid , pharmacokinetics , urinary system , midazolam , cytochrome p450 , chemistry , pharmacology , metabolism , sedation
Thyroid hormones have been shown to reduce the activity and expression of cytochrome P450 (CYP) 3A4 in vitro. The influence of thyroid hormone on drug action via a CYP3A‐dependent pathway has not been elucidated in humans. This is the first report showing the effect of thyroid hormone on CYP3A enzyme activity in humans. Ten healthy volunteers participate in this open‐label study, in which the pharmacokinetics of midazolam and the urinary ratios of 6 β‐hydroxycortisol/free cortisol before and after 2 weeks of oral administration of triiodothyronine were compared. Triiodothyronine administration significantly reduced the area under the concentration—time curve ratios for 1′‐hydroxymidazolam/midazolam from 0.36 to 0.25 ( P < .05) and urinary ratios of 6 β‐hydroxycortisol/free cortisol from 6.92 to 5.88 ( P < .05). These results strongly suggested that thyroid hormone reduced CYP3A activity in human and may influence the pharmacokinetics of concomitant CYP3A substrate drugs .