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Propofol Clearance and Volume of Distribution Are Increased in Patients With Major Burns
Author(s) -
Han TaeHyung,
Greenblatt David J.,
Martyn J. A. Jeevendra
Publication year - 2009
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270009335767
Subject(s) - propofol , pharmacokinetics , volume of distribution , medicine , anesthesia , plasma clearance , distribution (mathematics) , pharmacodynamics , plasma concentration , clearance rate , pharmacology , mathematical analysis , mathematics
Propofol pharmacokinetics were examined in 17 adults with major burns during the hyperdynamic convalescent phase. Eighteen nonburned surgical patients served as controls. After a 2‐mg/kg intravenous dose of propofol, blood samples were collected at multiple time points. Noncompartmental methods were used to calculate the pharmacokinetic parameters. The following indices were higher in burns than controls: propofol clearance (64 ± 17 vs 29 ± 4 mL/kg/min, P < .001) and volume of distribution (8 ± 3 vs 4 ± 1 L/kg, P < .001). The area under the curve was smaller in burns (556 ± 152 vs 1193 ± 183 μg/mL h, P < .001). The higher clearance of propofol in burned patients may imply that these patients require higher doses or infusion rates of propofol to attain a target plasma concentration or pharmacodynamic effect.