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Effects of Dexlansoprazole MR, a Novel Dual Delayed Release Formulation of a Proton Pump Inhibitor, on Plasma Gastrin Levels in Healthy Subjects
Author(s) -
Zhang Weijiang,
Wu Jingtao,
Atkinson Stuart N.
Publication year - 2009
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270008330155
Subject(s) - lansoprazole , proton pump inhibitor , crossover study , medicine , gastroenterology , pharmacology , omeprazole , placebo , alternative medicine , pathology
Dexlansoprazole MR is a modified release formulation of a proton pump inhibitor being developed for the treatment of acid‐related disorders. The purpose of this study is to characterize the plasma gastrin (PG) profile associated with administration of dexlansoprazole MR. Forty‐two healthy subjects receive dexlansoprazole MR 90 mg, dexlansoprazole MR 120 mg, and lansoprazole 30 mg once daily for 5 days in a randomized, open‐label, 3‐period crossover study with at least 14‐day washout intervals. Twenty‐four‐hour PG profiles are obtained at baseline (day – 1 of period 1) and on days 1 and 5 in each period. Fasting PG levels are determined on days 8 and 12 in periods 1 and 2. On day 1, 24‐hour PG levels increase from baseline to a similar extent with all regimens. On day 5, 24‐hour PG levels with both dexlansoprazole MR regimens increase further and to a similar extent and are slightly higher than PG levels with lansoprazole. For all regimens, fasting PG levels on days 5 and 6 are higher than baseline levels (P < .05) and start to decrease by day 8, returning to near baseline at day 12. In this study, dexlansoprazole MR administration results in moderate increases in PG, similar to lansoprazole, which return to baseline levels within 7 days post dosing.