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Ciprofloxacin Prolonged‐Release Tablets Do Not Affect Warfarin Pharmacokinetics and Pharmacodynamics
Author(s) -
Washington Carla,
Hou S. Y. Eddie,
Hughes Nicola C.,
Campanella Corinne,
Berner Bret
Publication year - 2007
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270007305504
Subject(s) - pharmacokinetics , warfarin , pharmacodynamics , ciprofloxacin , crossover study , medicine , pharmacology , prothrombin time , drug interaction , partial thromboplastin time , anticoagulant , antibiotics , chemistry , atrial fibrillation , coagulation , placebo , biochemistry , alternative medicine , pathology
The purpose of this study was to determine whether the pharmacokinetics of warfarin and ciprofloxacin PR (a prolonged‐release formulation of ciprofloxacin) were altered after coadministration. Eighteen healthy male volunteers were given a single oral 7.5‐mg dose of warfarin, a single oral 500‐mg dose of ciprofloxacin PR, or both drugs administered together in a randomized, open‐label, 3‐way crossover study. Ciprofloxacin concentrations, warfarin (R)‐ and (S)‐enantiomer concentrations, prothrombin time, and activated partial thromboplastin time were measured over 120 hours following study drug administration. There were no significant differences in pharmacokinetic or pharmacodynamic parameters among treatments. A slightly greater value of half‐life for (R)‐warfarin was observed when coadministered with ciprofloxacin PR compared with warfarin administered alone (52.6 vs 50.1 hours 1 P = .029). This difference is not considered clinically relevant, because the values remain similar. These results show that warfarin pharmacokinetics and pharmacodynamics are not altered with concomitant administration of ciprofloxacin PR.