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Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids
Author(s) -
Levêque Dominique,
Jehl François
Publication year - 2007
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270007299430
Subject(s) - vinca , catharanthus roseus , pharmacokinetics , pharmacology , alkaloid , vinca alkaloid , drug , transporter , medicine , chemistry , biochemistry , stereochemistry , gene , chemotherapy , vincristine , cyclophosphamide
This review focuses on the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of Catharanthus (vinca) alkaloids pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug‐drug interactions) is also discussed.