Premium
Selegiline Transdermal System: An Examination of the Potential for CYP450‐Dependent Pharmacokinetic Interactions With 3 Psychotropic Medications
Author(s) -
Azzaro Albert J.,
Ziemniak John,
Kemper Eva,
Campbell Bryan J.,
VanDenBerg Chad
Publication year - 2007
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270006296151
Subject(s) - pharmacology , pharmacokinetics , selegiline , bioequivalence , crossover study , medicine , antidepressant , drug interaction , alprazolam , placebo , psychiatry , anxiety , alternative medicine , disease , pathology , parkinson's disease , hippocampus
Selegiline transdermal system (STS) is a recently approved monoamine oxidase inhibitor antidepressant. This article reports results from 3 studies examining the potential for cytochrome P450–dependent pharmacokinetic interactions between STS and 3 psychotropic medications that might be coadministered. Three open‐label, randomized, Latin square, 3‐sequence crossover design studies were conducted with healthy volunteers to determine the pharmacokinetic parameters of STS 6 mg/24 h and test drug (alprazolam, olanzapine, or risperidone) when administered alone and concomitantly. All pharmacokinetic parameters of interest were unaltered following selegiline or test drug monotherapy when compared to concomitant therapy. This was confirmed by least squares mean ratios and their 90% confidence intervals of log e ‐transformed C max and AUC τ values, using either standard bioequivalence criteria of 80% to 125% or study‐defined 70% to 143% boundary criteria. These results demonstrate that STS 6 mg/24 h may provide an antidepressant option that is unlikely to result in CYP450‐mediated pharmacokinetic drug‐drug interactions.