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Antimalarial Drug Therapy: The Role of Parasite Biology and Drug Resistance
Author(s) -
Daily Johanna P.
Publication year - 2006
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270006294276
Subject(s) - malaria , drug resistance , drug , context (archaeology) , disease , infectious disease (medical specialty) , biology , public health , plasmodium falciparum , plasmodium (life cycle) , intensive care medicine , medicine , pharmacology , immunology , parasite hosting , pathology , microbiology and biotechnology , paleontology , world wide web , computer science
Malaria continues to affect public health and economic growth in many regions of the world. The number of infections continues to rise and is associated with increased mortality, despite basic science and public health efforts. Drug therapy remains the mainstay of treatment and prevention of this disease. Plasmodium has a complex life cycle involving an arthropod vector and distinct stages within the human host. Each parasite stage plays a unique role in transmission, disease, and latency. These different stages may vary in their response to the various antimalarial compounds. This article will review antimalarial therapies and drug resistance in the context of the parasites' biology.