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Pharmacokinetic/Pharmacodynamic Modeling of Pegfilgrastim in Healthy Subjects
Author(s) -
Roskos Lorin K.,
Lum Peggy,
Lockbaum Pamela,
Schwab Gisela,
Yang BingBing
Publication year - 2006
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270006288731
Subject(s) - pegfilgrastim , pharmacokinetics , medicine , pharmacodynamics , pharmacology , filgrastim , absolute neutrophil count , granulocyte colony stimulating factor , chemotherapy , neutropenia
This analysis was conducted to characterize the pharmacokinetics and pharmacodynamics of pegfilgrastim and to develop a pharmacokinetic‐pharmacodynamic model to describe the granulopoietic effects of pegfilgrastim and the homeostatic regulation of pegfilgrastim clearance in healthy subjects. Pegfilgrastim serum concentration data and differential white cell counts were obtained from an open‐label, single‐dose, dose escalation study. Healthy subjects (8 subjects/dose group) received a single subcutaneous dose of 30, 60, 100, or 300 μg/kg pegfilgrastim. Pegfilgrastim exhibited nonlinear pharmacokinetics; clearance decreased with increasing dose. A dose‐dependent increase in absolute neutrophil count with an increase in the percentage of band cells was observed. A pharmacokinetic‐pharmacodynamic model was developed that adequately described the nonlinear pharmacokinetics of pegfilgrastim, feedback regulation of pegfilgrastim clearance by neutrophils, and the differential effects of pegfilgrastim on neutrophil populations in blood.