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Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use
Author(s) -
Zhou Limin,
Zuo Zhong,
Chow Moses Sing Sum
Publication year - 2005
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270005282630
Subject(s) - salvia miltiorrhiza , medicine , clinical trial , pharmacology , angina , intensive care medicine , traditional chinese medicine , pharmacokinetics , traditional medicine , drug , stroke (engine) , alternative medicine , myocardial infarction , pathology , mechanical engineering , engineering
Danshen, the dried root of Salvia miltiorrhiza, has been widely used in China and, to a lesser extent, in Japan, the United States, and other European countries for the treatment of cardiovascular and cerebrovascular diseases. In China, the specific clinical use is angina pectoris, hyperlipidemia, and acute ischemic stroke. The current review covers its traditional uses, chemical constituents, pharmacological activities, pharmacokinetics, clinical applications, and potential herb‐drug interactions based on information obtained in both the English and Chinese literature. Although numerous clinical trials have demonstrated that certain Danshen products in China are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its mechanism of actions will be necessary to ensure the safety, effectiveness, and better understanding of its action .