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Population Pharmacokinetic Analysis of Dalbavancin, a Novel Lipoglycopeptide
Author(s) -
Buckwalter Mary,
Dowell James A.
Publication year - 2005
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270005280378
Subject(s) - dalbavancin , pharmacokinetics , body surface area , medicine , volume of distribution , concomitant , population , pharmacology , nonmem , antibiotics , biology , microbiology and biotechnology , vancomycin , environmental health , bacteria , genetics , staphylococcus aureus
Dalbavancin is a lipoglycopeptide antibiotic in clinical development as a once‐weekly treatment for serious infections. A total of 532 patients, consisting of 502 patients with skin and soft tissue infections requiring parenteral therapy and 30 patients with catheter‐related bloodstream infections, was available for population pharmacokinetic analysis. The majority of patients (78.4%) received dalbavancin intravenously as a 1000‐mg dose on day 1 and a single 500‐mg dose on day 8. A 2‐compartment model with first‐order elimination provided the best fit to the data. The clearance of dalbavancin was influenced by body surface area and creatinine clearance, but together they described less than 25% of the interpatient variability. Body surface area was determined to be a predictor of the central volume of distribution. There was no evidence that the presence of metabolic substrates, inhibitors, or inducers of cytochrome P450 or selected concomitant medications influenced the clearance of dalbavancin.