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Systemic and Renal Pharmacokinetics of Adefovir and Tenofovir Upon Coadministration
Author(s) -
Kearney Brian P.,
Ramanathan Srinivasan,
Cheng Andrew K.,
Ebrahimi Ramin,
Shah Jaymin
Publication year - 2005
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270005278949
Subject(s) - adefovir , tenofovir , pharmacokinetics , pharmacology , medicine , pharmacokinetic interaction , drug interaction , human immunodeficiency virus (hiv) , virology , lamivudine , hepatitis b virus , virus
Adefovir and tenofovir are nucleotide analogs that undergo renal secretion by the human renal organic anion transporter. The pharmacokinetics of tenofovir and adefovir following the administration of tenofovir disoproxil fumarate and adefovir dipivoxil alone and together were determined in 24 healthy subjects in an 8‐day, open‐label, fixed‐sequence study. Subjects received oral doses of adefovir dipivoxil on days 1 and 8 and oral doses of tenofovir disoproxil fumarate on days 2 to 8. Pharmacokinetic sampling was performed on days 1, 7, and 8. The plasma pharmacokinetics of tenofovir and adefovir were unaltered upon coadministration. Furthermore, the renal clearances (CL renal ) of tenofovir and adefovir were unaffected by their coadministration. The plasma C max values of tenofovir and adefovir were 33‐fold and 340‐fold lower than their K m values for the human renal organic anion transporter. These results demonstrate that coadministration of tenofovir disoproxil fumarate and adefovir dipivoxil does not result in substantial changes to their individual pharmacokinetic profiles.