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Glycoprotein IIb/IIIa Receptor Antagonists and Risk of Bleeding: A Single‐Center Experience in 1020 Patients
Author(s) -
Ali Arshad,
Hashem Mustafa,
Rosman Howard S.,
Moser Lynette,
Rehan Arshad,
Davis Thomas,
Romanelli Michael,
LaLonde Thomas,
Yamasaki Hiroshi,
Barbish Brian,
Michael Julia,
Ali Shamsa A.,
Schreiber Theodore L.,
Gardin Julius M.
Publication year - 2004
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270004269559
Subject(s) - medicine , myocardial infarction , odds ratio , partial thromboplastin time , timi , population , surgery , heart failure , percutaneous coronary intervention , platelet , environmental health
The safety of glycoprotein (GP) IIb/IIIa inhibitors has been well documented in clinical trials. Although these trials have included a broad patient population, the strict enrollment criteria may have resulted in exclusion of patients at a higher risk of bleeding complications. The authors conducted a retrospective chart review of 1020 consecutive patients who received GP IIb/IIIa inhibitors and underwent percutaneous coronary intervention in a large community hospital. They used Thrombolysis in Myocardial Infarction (TIMI) criteria to define major or minor bleeding complications. Bleeding complications developed in 214 (21%) patients, with major bleeding in 89 (9%). Univariate predictors of bleeding were older age, lower body weight, elevated serum creatinine, higher activated partial thromboplastin time (aPTT) level, history of diabetes mellitus (DM), peripheral vascular disease (PVD), congestive heart failure (CHF), and emergency procedure for acute myocardial infarction (AMI). Multivariate predictors of major bleeding were PVD (20% in bleeding group vs 11% in nonbleeders, odds ratio [OR] = 1.8, 95% confidence interval [CI] = 1.2–2.6, P < .004), age (68 ± 2 years, 95% CI = 66–70 in bleeding group vs 63 ± 13 years, 95% CI = 61.2–63 in nonbleeders, P < .001), and higher aPTT level (66 ± 27 seconds, 95% CI = 63–70 in bleeding group vs 53 ± 28 seconds, 95% CI = 51–56 in nonbleeders, P < .001). The risk of bleeding in the large community hospital setting may be higher than in randomized clinical trials. This increased risk is associated with higher hospitalization costs. Recognition of predictors of bleeding should further enhance the safety of these antiplatelet agents.