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Influence of Simulated Weightlessness on the Oral Pharmacokinetics of Acetaminophen as a Gastric Emptying Probe in Man: A Plasma and a Saliva Study
Author(s) -
Gandia Peggy,
Bareille MariePierre,
Saivin Sylvie,
LeTraon Anne Pavy,
Lavit Michel,
Guell Antonio,
Houin Georges
Publication year - 2003
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/0091270003257229
Subject(s) - cmax , saliva , gastric emptying , pharmacokinetics , acetaminophen , chemistry , absorption (acoustics) , pharmacology , medicine , stomach , biochemistry , physics , acoustics
This study evaluated the effect of simulated weightlessness on gastric emptying, using acetaminophen as a probe and −6° head‐down bed rest to simulate zero gravity. Eighteen volunteers were given 1 g of acetaminophen orally before the bed rest and at days 1, 18, and 80. C max , t max , AUC 0‐∞ , AUC 0‐t , and t 1/2 were calculated for plasma and saliva. The plasma C max showed a significant increase (10.43 μg/mL [day 1] to 14.74 μg/mL [day 80]), while t max significantly decreased (1.41 h [day 1] to 0.91 h [day 80]). Similar results were obtained with saliva, and there were significant increases in the AUCs. The good correlation between the plasma and saliva data suggests that saliva sampling can be valid for acetaminophen pharmacokinetics. The changes in C max and t max indicated more rapid drug absorption, which could have been as a result of faster gastric emptying or an increased blood flow to the intestine .