Premium
Acute Encephalopathy Due to Aluminum Toxicity Successfully Treated by Combined Intravenous Deferoxamine and Hemodialysis
Author(s) -
Nakamura Hidefumi,
Rose Peter G.,
Blumer Jeffrey L.,
Reed Michael D.
Publication year - 2000
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/00912700022008847
Subject(s) - deferoxamine , medicine , hemodialysis , encephalopathy , regimen , toxicity , intensive care medicine , dialysis , toxic encephalopathy , surgery
Acute aluminum intoxication is uncommon in clinical practice but can be fatal. This limited experience is reflected in the paucity of data assessing a viable approach to the treatment of these patients. In this report, the authors describe the clinical course and successful, pharmacokinetic‐based deferoxamine‐hemodialysis treatment regimen of a patient with severe aluminum encephalopathy following alum bladder irrigation. The combined use of deferoxamine and appropriately timed hemodialysis appears to be a very reasonable means of treating patients with severe acute aluminum intoxication.