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Pharmacokinetics and Bioavailability of a Metformin/Glyburide Tablet Administered Alone and with Food
Author(s) -
Marathe P. H.,
Arnold M. E.,
Meeker Jeff,
Greene D. S.,
Barbhaiya R. H.
Publication year - 2000
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127000004001222
Subject(s) - bioavailability , bioequivalence , metformin , pharmacokinetics , crossover study , pharmacology , medicine , glibenclamide , endocrinology , diabetes mellitus , insulin , placebo , alternative medicine , pathology
Two randomized crossover studies were conducted to evaluate the pharmacokinetics (including food effect) of fixed‐combination metformin/glyburide tablets. Pharmacokinetics and bioavailability of two strengths (500 mg/2.5 mg and 500 mg/5 mg) of metformin/glyburide tablets were assessed relative to coadministered metformin and glyburide tablets in study 1. The effect of a high‐fat meal on the bioavailability of a metformin/glyburide (500 mg/5 mg) tablet was assessed relative to the fasted condition in study 2. The fixed combination metformin/glyburide tablets showed bioequivalence for the metformin component with the reference metformin tablet and comparable bioavailability for the glyburide component with the reference glyburide tablet. Food does not appear to affect the bioavailability of either component to an appreciable extent.