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Pharmacokinetic and Pharmacodynamic Comparison of Two Calcium Supplements in Postmenopausal Women
Author(s) -
Heller Howard J.,
Greer Laura G.,
Haynes Sharon D.,
Poindexter John R.,
Pak Charles Y. C.
Publication year - 2000
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1177/009127000004001108
Subject(s) - calcium , crossover study , bioavailability , pharmacokinetics , calcium carbonate , endocrinology , parathyroid hormone , urinary calcium , medicine , chemistry , placebo , urine , pharmacodynamics , pharmacology , alternative medicine , organic chemistry , pathology
This randomized crossover study compared the single‐dose bioavailability and effects on parathyroid function of two commercially formulated calcium supplements containing 500 mg of elemental calcium. Twenty‐five postmenopausal women underwent three phases of study wherein they each took a single dose of calcium citrate with a standard breakfast (as Citracal® 250 mg + D), calcium carbonate (as Os‐Cal ®500 mg + D), or placebo at 8 a.m. Blood samples were drawn at baseline and hourly for 4 or 6 hours after each dose. Fasting and postload urine samples were also collected. Compared with calcium carbonate, calcium citrate provided a 46% greater peak‐basal variation and 94% higher change in area under the curve for serum calcium and a 41% greater increment in urinary calcium. Moreover, the decrement in serum parathyroid hormone concentration from baseline was greater after calcium citrate. In conclusion, calcium citrate is more bioavailable than calcium carbonate when given with a meal.