Open AccessInductive Materials for Regenerative Engineering
Author(s) -
Fatemeh S. Hosseini,
Lakshmi S. Nair,
Cato T. Laurencin
Publication year - 2021
Publication title -
journal of dental research
Language(s) - English
Resource type - Journals
eISSN - 1544-0591
pISSN - 0022-0345
DOI - 10.1177/00220345211010436
Subject(s) - regenerative medicine , tissue engineering , regeneration (biology) , nanotechnology , stem cell , materials science , biomedical engineering , medicine , biology , microbiology and biotechnology
Regenerative engineering has pioneered several novel biomaterials to treat critical-sized bone injuries. However, despite significant improvement in synthetic materials research, some limitations still exist. The constraints correlated with the current grafting methods signify a treatment paradigm shift to osteoinductive regenerative engineering approaches. Because of their intrinsic potential, inductive biomaterials may represent alternative approaches to treating critical bone injuries. Osteoinductive scaffolds stimulate stem cell differentiation into the osteoblastic lineage, enhancing bone regeneration. Inductive biomaterials comprise polymers, calcium phosphate ceramics, metals, and graphene family materials. This review will assess the cellular behavior toward properties of inductive materials.