Open AccessChanges in cortical N-methyl-d -aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide
Author(s) -
Brian Dean,
Andrew S. Gibbons,
Simone Boer,
Akihito Uezato,
James H. MeadorWoodruff,
Elizabeth Scarr,
Robert E. McCullumsmith
Publication year - 2015
Publication title -
australian and new zealand journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.66
H-Index - 116
eISSN - 1440-1614
pISSN - 0004-8674
DOI - 10.1177/0004867415586601
Subject(s) - dorsolateral prefrontal cortex , nmda receptor , anterior cingulate cortex , prefrontal cortex , neuroscience , schizophrenia (object oriented programming) , psychology , glutamate receptor , bipolar disorder , medicine , endocrinology , psychiatry , receptor , cognition
In humans, depending on dose, blocking the N-methyl-D-aspartate receptor (NMDAR) with ketamine can cause psychomimetic or antidepressant effects. The overall outcome for drugs such as ketamine depends on dose and the number of its available binding sites in the central nervous system, and to understand something of the latter variable we measure NMDAR in the frontal pole, dorsolateral prefrontal, anterior cingulate and parietal cortices from people with schizophrenia, bipolar disorder, major depressive disorders and age/sex matched controls.