Open AccessAssociation of Mast Cell Burden and TIM-3 Expression with Recalcitrant Chronic Rhinosinusitis with Nasal Polyps
Author(s) -
Michael A. Belsky,
Erica Corredera,
Hridesh Banerjee,
John Bassett Moore,
Li Wang,
Lawrence P. Kane,
Stella E. Lee
Publication year - 2021
Publication title -
the annals of otology, rhinology and laryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.65
H-Index - 91
eISSN - 1943-572X
pISSN - 0003-4894
DOI - 10.1177/0003489421995038
Subject(s) - mast cell , nasal polyps , medicine , stromal cell , immunology , functional endoscopic sinus surgery , tryptase , pathology , sinusitis , gastroenterology
Previous work showed that higher polyp mast cell load correlated with worse postoperative endoscopic appearance in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Polyp epithelial mast cells showed increased expression of T-cell/transmembrane immunoglobulin and mucin domain protein 3 (TIM-3), a receptor that promotes mast cell activation and cytokine production. In this study, CRSwNP patients were followed post-operatively to investigate whether mast cell burden or TIM-3 expression among mast cells can predict recalcitrant disease.