Open AccessMetabolomic Expression of Laryngeal and Hindlimb Muscles in Adult versus Senescent Rats
Author(s) -
Adrianna C. Shembel,
Yik Siu,
Tenzin Lhakhang,
Leonard J. Ash,
Drew R. Jones,
Aaron M. Johnson
Publication year - 2021
Publication title -
the annals of otology, rhinology and laryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.65
H-Index - 91
eISSN - 1943-572X
pISSN - 0003-4894
DOI - 10.1177/00034894211014692
Subject(s) - hindlimb , metabolite , metabolome , larynx , metabolomics , skeletal muscle , leg muscle , biology , anatomy , endocrinology , medicine , bioinformatics , physical medicine and rehabilitation
(1) Determine the feasibility of obtaining a global, unbiased metabolomic profile on laryngeal muscle in a rat model; (2) evaluate the impact of biological aging on the laryngeal metabolome; and (3) characterize biochemical expression differences between aged and non-aged laryngeal and hindlimb muscle.