Open AccessStem Cell–Mediated Paracrine Signaling Alters Fibroplasia in Human Vocal Fold Fibroblasts in Vitro
Author(s) -
Nao Hiwatashi,
Renjie Bing,
Iv Kraja,
Ryan C. Branski
Publication year - 2017
Publication title -
the annals of otology, rhinology and laryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.65
H-Index - 91
eISSN - 1943-572X
pISSN - 0003-4894
DOI - 10.1177/0003489417716186
Subject(s) - mesenchymal stem cell , paracrine signalling , downregulation and upregulation , transforming growth factor , microbiology and biotechnology , stimulation , transforming growth factor beta , chemistry , cell growth , endocrinology , medicine , biology , biochemistry , receptor , gene
Interactions between mesenchymal stem cells (MSCs) and native vocal fold fibroblasts (VFFs) have not been described in spite of promising preliminary data regarding the effects of MSCs on vocal fold repair in vivo. The current study employed a conditioned media (CM) model to investigate the paracrine effects of bone marrow-derived mesenchymal stem cells (BMSCs) on VFFs.