Open AccessPathologic Complete Response Following Neoadjuvant Therapy for Gastric Adenocarcinoma: A National Cancer Database Analysis on Incidence, Predictors, and Outcomes
Author(s) -
Christof Kaltenmeier,
Alison R. Althans,
Maria Mascara,
Ibrahim Nassour,
Sidrah Khan,
Richard S. Hoehn,
Amer H. Zureikat,
Samer Tohme
Publication year - 2020
Publication title -
the american surgeon/american surgeon
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 93
eISSN - 1555-9823
pISSN - 0003-1348
DOI - 10.1177/0003134820972083
Subject(s) - medicine , neoadjuvant therapy , oncology , cancer , adenocarcinoma , chemotherapy , radiation therapy , breast cancer
With advances in multimodal therapy, survival rates in gastric cancer have significantly improved over the last two decades. Neoadjuvant therapy increases the likelihood of achieving negative margins and may even lead to pathologic complete response (pCR). However, the impact of pCR on survival in gastric cancer has been poorly described. We analyzed the rate and predictors of pCR in patients receiving neoadjuvant therapy as well as impact of pCR on survival.