Open AccessNeural Correlates of Automatic and Controlled Auditory Processing in Schizophrenia
Author(s) -
Rajendra A. Morey,
Teresa V. Mitchell,
Seniha Inan,
Jeffrey A. Lieberman,
Ayşenil Belger
Publication year - 2008
Publication title -
the journal of neuropsychiatry and clinical neurosciences/the journal of neuropsychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 108
eISSN - 1545-7222
pISSN - 0895-0172
DOI - 10.1176/jnp.2008.20.4.419
Subject(s) - schizophrenia (object oriented programming) , neural correlates of consciousness , psychology , audiology , neuroscience , mismatch negativity , cognitive psychology , electroencephalography , medicine , psychiatry , cognition
Individuals with schizophrenia demonstrate impairments in selective attention and sensory processing. The authors assessed differences in brain function between 26 participants with schizophrenia and 17 comparison subjects engaged in automatic (unattended) and controlled (attended) auditory information processing using event-related functional MRI. Lower regional neural activation during automatic auditory processing in the schizophrenia group was not confined to just the temporal lobe, but also extended to prefrontal regions. Controlled auditory processing was associated with a distributed frontotemporal and subcortical dysfunction. Differences in activation between these two modes of auditory information processing were more pronounced in the comparison group than in the patient group.