Open AccessPreliminary Study of the Association of White-Matter Metabolite Concentrations With Disease Severity in Patients With Huntington’s Disease
Author(s) -
Jeffrey R. Yager,
Charles Gasparovic,
Vincent A. Magnotta,
William Adams,
Jess G. Fiedorowicz,
Jane S. Paulsen,
Ricardo E. Jorge,
Leigh J. Beglinger
Publication year - 2014
Publication title -
the journal of neuropsychiatry and clinical neurosciences/the journal of neuropsychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 108
eISSN - 1545-7222
pISSN - 0895-0172
DOI - 10.1176/appi.neuropsych.13020040
Subject(s) - white matter , metabolite , huntington's disease , disease , medicine , proton magnetic resonance , magnetic resonance imaging , nuclear magnetic resonance , physics , radiology
Proton magnetic resonance spectroscopy is used to measure several metabolites in cortical gray and white matter in patients with Huntington's disease. The preliminary results show that CAG-repeat length correlates with white-matter N-acetylaspartate concentrations, and disease severity correlates with several metabolites.