Open AccessPerimenopause and First-Onset Mood Disorders: A Closer Look
Author(s) -
Natalie Musial,
Z Ali,
Jennifer Grbevski,
Ashan Veerakumar,
Priya Sharma
Publication year - 2021
Publication title -
focus/focus (american psychiatric publishing. online)
Language(s) - English
Resource type - Journals
eISSN - 1541-4108
pISSN - 1541-4094
DOI - 10.1176/appi.focus.20200041
Subject(s) - bipolar disorder , mood disorders , mood , psychology , psychiatry , clinical psychology , population , medicine , anxiety , environmental health
Perimenopause is often a time of social, emotional, and physical change. Various factors contribute to the development of mood disorders during this time. There is a known association among women with previous history of major depressive disorder or bipolar disorder and relapse during the menopausal transition. First-onset mood disorders during this time have been less studied. A literature review in PsycInfo Ovid of records pertaining to first-onset mood disorders during perimenopause showed that this multifactorial process involves hormonal fluctuations, with estrogen being a key player. In addition, vasomotor symptoms, previous negative life events, and socioeconomic status were found to contribute to first-onset mood disorders during perimenopause. Treatment options include established medication regimens for psychiatric conditions; however, hormone therapy also has proven beneficial for this patient population. Further research, particularly on bipolar disorder, is needed to develop a clear association between perimenopause and first-onset mood disorders.