Open AccessEffects of Gabapentin on Dorsal Anterior Cingulate Cortex GABA and Glutamate Levels and Their Associations With Abstinence in Alcohol Use Disorder: A Randomized Clinical Trial
Author(s) -
James J. Prisciandaro,
Michaéla Hoffman,
Truman R. Brown,
Konstantin Voronin,
Sarah W. Book,
Emily Bristol,
Raymond F. Anton
Publication year - 2021
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2021.20121757
Subject(s) - anterior cingulate cortex , gabapentin , abstinence , glutamate receptor , neuroscience , cingulate cortex , randomized controlled trial , alcohol , psychology , alcohol use disorder , dorsum , psychiatry , medicine , anesthesia , clinical psychology , central nervous system , cognition , biology , anatomy , biochemistry , alternative medicine , receptor , pathology
Although gabapentin has demonstrated efficacy in mitigating alcohol withdrawal symptoms and preventing relapse drinking in individuals with alcohol use disorder (AUD), the neurobiological mechanisms of action underlying these therapeutic effects remain unknown. The present study evaluated changes in GABA and glutamate levels in the dorsal anterior cingulate cortex (dACC) as candidate mechanisms of action.