Open AccessBrain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Author(s) -
Jennifer S. Stevens,
Nathaniel G. Harnett,
Lauren A. M. Lebois,
Sanne J.H. van Rooij,
Timothy D. Ely,
Alyssa R. Roeckner,
Nico Vincent,
Francesca L. Beaudoin,
Xiuli An,
Donglin Zeng,
Thomas C. Neylan,
Gari D. Clifford,
Sarah D. Linnstaedt,
Laura Germine,
Scott L. Rauch,
Christopher Lewandowski,
Alan B. Storrow,
Phyllis L. Hendry,
Sophia Sheikh,
Paul I. Musey,
John P. Haran,
Christopher W. Jones,
Brittany E. Punches,
Michael S. Lyons,
Michael C Kurz,
Meghan E. McGrath,
José L. Pascual,
Elizabeth M. Datner,
Anna Marie Chang,
Claire Pearson,
David A. Peak,
Robert M. Domeier,
Brian J. O’Neil,
Niels K. Rathlev,
León D. Sánchez,
Robert H. Pietrzak,
Jutta Joormann,
M Deanna,
Diego A. Pizzagalli,
John F. Sheridan,
Beatríz Luna,
Steven E. Harte,
James M. Elliott,
Vishnu P. Murty,
Tanja Jovanović,
Steven E. Bruce,
Stacey L. House,
Ronald C. Kessler,
Karestan C. Koenen,
Samuel A. McLean,
Kerry J. Ressler
Publication year - 2021
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2021.20101526
Subject(s) - psychopathology , neuroimaging , cohort , medicine , longitudinal study , clinical psychology , vulnerability (computing) , psychological resilience , psychiatry , mental health , posttraumatic stress , psychology , pathology , computer security , computer science , psychotherapist
Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations.