Open AccessA Longitudinal Study of Resting-State Connectivity and Response to Psychostimulant Treatment in ADHD
Author(s) -
Luke Norman,
Gustavo Sudre,
Marine Bouyssi-Kobar,
Wendy Sharp,
Philip Shaw
Publication year - 2021
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2021.20091342
Subject(s) - methylphenidate , resting state fmri , default mode network , psychology , amphetamine , functional connectivity , attention deficit hyperactivity disorder , neuroimaging , neurodevelopmental disorder , medicine , psychiatry , audiology , neuroscience , autism , dopamine
Psychostimulants are first-line pharmacological treatments for attention deficit hyperactivity disorder (ADHD), although symptom reduction varies widely between patients and these individual differences in treatment response are poorly understood. The authors sought to examine whether the resting-state functional connectivity within and between cingulo-opercular, striato-thalamic, and default mode networks was associated with treatment response to psychostimulant medication, and whether this relationship changed with development.