Open AccessModeration of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms
Author(s) -
Rajita Sinha,
Stephanie Wemm,
Nia Fogelman,
Verica Milivojevic,
Peter M Morgan,
Gustavo A. Angarita,
Gretchen Hermes,
Helen Fox
Publication year - 2021
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2020.20050609
Subject(s) - craving , placebo , medicine , alcohol use disorder , anxiety , alcohol , prazosin , alcohol dependence , mood , randomized controlled trial , odds ratio , psychiatry , addiction , antagonist , biochemistry , chemistry , alternative medicine , receptor , pathology
Alcohol use disorder (AUD) is a leading cause of global disease burden. Chronic, heavy use increases the likelihood of alcohol withdrawal symptoms and associated secondary outcomes of alcohol craving and mood, anxiety, and sleep disturbances, which are predictive of poor treatment outcomes. The authors examined whether alcohol withdrawal symptoms moderate the efficacy of prazosin in reducing alcohol intake and associated secondary outcomes.