Open AccessEvidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI
Author(s) -
Clifford Cassidy,
Kenneth M. Carpenter,
Anna B. Konova,
Victoria Cheung,
Alexander Grassetti,
Luigi Zecca,
Anissa AbiDargham,
Diana Martínez,
Guillermo Horga
Publication year - 2020
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2020.20010090
Subject(s) - substantia nigra , dopamine , neuromelanin , neuroscience , striatum , psychology , medicine , dopaminergic
Recent evidence supports the use of neuromelanin-sensitive MRI (NM-MRI) as a novel tool to investigate dopamine function in the human brain. The authors investigated the NM-MRI signal in individuals with cocaine use disorder, compared with age- and sex-matched control subjects, based on previous imaging studies showing that this disorder is associated with blunted presynaptic striatal dopamine.