Open AccessParietal-Prefrontal Feedforward Connectivity in Association With Schizophrenia Genetic Risk and Delusions
Author(s) -
Danielle L.B. Greenman,
Michelle La,
Syed Shaheen Shah,
Qiang Chen,
Karen F. Berman,
Daniel R. Weinberger,
Heok Hui Tan
Publication year - 2020
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2020.19111176
Subject(s) - schizophrenia (object oriented programming) , association (psychology) , neuroscience , psychology , genetic association , functional connectivity , cognitive psychology , psychiatry , genetics , biology , psychotherapist , single nucleotide polymorphism , genotype , gene
Conceptualizations of delusion formation implicate deficits in feedforward information updating across the posterior to prefrontal cortices, resulting in dysfunctional integration of new information about contexts in working memory and, ultimately, failure to update overfamiliar prior beliefs. The authors used functional MRI and machine learning models to address individual variability in feedforward parietal-prefrontal information updating in patients with schizophrenia. They examined relationships between feedforward connectivity, and delusional thinking and polygenic risk for schizophrenia.