Open AccessPervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology
Author(s) -
Adrienne L. Romer,
M. Elliott,
Annchen R. Knodt,
Maria L. Sison,
David Ireland,
Renate Houts,
Sandhya Ramrakha,
Richie Poulton,
Rāwiri Keenan,
Tracy R. Melzer,
Terrie E. Moffitt,
Avshalom Caspi,
Ahmad R. Hariri
Publication year - 2021
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2020.19090934
Subject(s) - psychopathology , comorbidity , psychology , neuroimaging , clinical psychology , etiology , dysfunctional family , psychiatry , neuropsychology , cognition
Neuroimaging research has revealed that structural brain alterations are common across broad diagnostic families of disorders rather than specific to a single psychiatric disorder. Such overlap in the structural brain correlates of mental disorders mirrors already well-documented phenotypic comorbidity of psychiatric symptoms and diagnoses, which can be indexed by a general psychopathology or p factor. The authors hypothesized that if general psychopathology drives the convergence of structural alterations common across disorders, then 1) there should be few associations unique to any one diagnostic family of disorders, and 2) associations with the p factor should overlap with those for the broader diagnostic families.