Open AccessAltered Cellular White Matter But Not Extracellular Free Water on Diffusion MRI in Individuals at Clinical High Risk for Psychosis
Author(s) -
Yingying Tang,
Ofer Pasternak,
Marek Kubicki,
Yogesh Rathi,
Tianhong Zhang,
Junjie Wang,
Huijun Li,
Kristen A. Woodberry,
Li-Hua Xu,
Zhenying Qian,
Angela Zhu,
Susan WhitfieldGabrieli,
Matcheri S. Keshavan,
Margaret A. Niznikiewicz,
William S. Stone,
Robert W. McCarley,
Martha E. Shenton,
Jijun Wang,
Larry J. Seidman
Publication year - 2019
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2019.18091044
Subject(s) - psychosis , white matter , extracellular , diffusion mri , neuroscience , psychology , medicine , psychiatry , magnetic resonance imaging , biology , microbiology and biotechnology , radiology
Detecting brain abnormalities in clinical high-risk populations before the onset of psychosis is important for tracking pathological pathways and for identifying possible intervention strategies that may impede or prevent the onset of psychotic disorders. Co-occurring cellular and extracellular white matter alterations have previously been implicated after a first psychotic episode. The authors investigated whether or not cellular and extracellular alterations are already present in a predominantly medication-naive cohort of clinical high-risk individuals experiencing attenuated psychotic symptoms.