Open AccessNeurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder
Author(s) -
Laura E. Kwako,
Melanie L. Schwandt,
Vijay A. Ramchandani,
Nancy Diazgranados,
George F. Koob,
Nora D. Volkow,
Carlos Blanco,
David Goldman
Publication year - 2019
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.2018.18030357
Subject(s) - incentive salience , psychology , alcohol use disorder , clinical psychology , addiction , cognition , dysfunctional family , neuroimaging , emotionality , developmental psychology , psychiatry , alcohol , biochemistry , chemistry
The authors evaluated whether three neurofunctional domains proposed to be critical in the addiction cycle, namely, incentive salience, negative emotionality, and executive function, could be identified through factor analysis of a deeply phenotyped clinical sample.