The effect of zidovudine on neuropsychiatric measures in HIV-infected men | Zendy

Jack M. Gorman | Zendy; Richard Mayeux | Zendy; Yaakov Stern | Zendy; Janet B. W. Williams | Zendy; Judith G. Rabkin | Zendy; Raymond R. Goetz | Zendy; Anke Α. Ehrhardt | Zendy

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The effect of zidovudine on neuropsychiatric measures in HIV-infected men

Author(s) -

Jack M. Gorman,

Richard Mayeux,

Yaakov Stern,

Janet B. W. Williams,

Judith G. Rabkin,

Raymond R. Goetz,

Anke Α. Ehrhardt

Publication year - 1993

Publication title -

american journal of psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.477

H-Index - 353

eISSN - 1535-7228

pISSN - 0002-953X

DOI - 10.1176/ajp.150.3.505

Subject(s) - zidovudine , human immunodeficiency virus (hiv) , virology , medicine , psychiatry , psychology , viral disease

The authors examined the effects of zidovudine on neuropsychiatric measures, at three assessment points separated by 6 months, in 25 HIV-positive men who took zidovudine for at least 6 months and a comparison group of 25 HIV-positive men with similar CD4+ T cell counts who had never taken zidovudine. Zidovudine had no statistically significant effect except for a slight improvement in Global Assessment of Functioning scale score. In this small group of subjects there was little benefit but also little evidence of CNS toxicity from zidovudine.

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