HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork | Zendy

Jaclyn Y. Bermudez | Zendy; Hannah C. Webber | Zendy; Gaurang Patel | Zendy; Xiangyang Liu | Zendy; YiQiang Cheng | Zendy; Abbot F. Clark | Zendy; Weiming Mao | Zendy

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HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork

Author(s) -

Jaclyn Y. Bermudez,

Hannah C. Webber,

Gaurang Patel,

Xiangyang Liu,

YiQiang Cheng,

Abbot F. Clark,

Weiming Mao

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs16-19446

Subject(s) - trabecular meshwork , acetylation , histone deacetylase inhibitor , microbiology and biotechnology , histone deacetylase , chromatin immunoprecipitation , histone , glaucoma , chromatin , chemistry , biology , gene expression , biochemistry , dna , gene , promoter , neuroscience

Elevated intraocular pressure (IOP) in primary open-angle glaucoma (POAG) results from glaucomatous damage to the trabecular meshwork (TM). The glaucoma-associated factor TGFβ2 is increased in aqueous humor and TM of POAG patients. We hypothesize that histone acetylation has a role in dysregulated TGFβ2 expression.

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