Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice | Zendy

Wanting Shu | Zendy; Bailey Baumann | Zendy; Ying Song | Zendy; Yingrui Liu | Zendy; Xingwei Wu | Zendy; Joshua L. Dunaief | Zendy

Open Access

Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice

Author(s) -

Wanting Shu,

Bailey Baumann,

Ying Song,

Yingrui Liu,

Xingwei Wu,

Joshua L. Dunaief

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-28250

Subject(s) - hepcidin , retinal , retina , ferritin , retinal degeneration , iron deficiency , dextran , immunology , endocrinology , medicine , biology , anemia , biochemistry , neuroscience

Iron supplementation therapy is used for iron-deficiency anemia but has been associated with macular degeneration in a 43-year-old patient. Iron entry into the neurosensory retina (NSR) can be toxic. It is important to determine conditions under which serum iron might cross the blood retinal barrier (BRB) into the NSR. Herein, an established mouse model of systemic iron overload using high-dose intraperitoneal iron dextran (IP FeDex) was studied. In addition, because the NSR expresses the iron regulatory hormone hepcidin, which could limit iron influx into the NSR, we gave retina-specific hepcidin knockout (RS-HepcKO) mice IP FeDex to test this possibility.

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