Open AccessChitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration
Author(s) -
Nana Xu,
Qiyu Bo,
Rong Shao,
Jian Liang,
Yadi Zhai,
Sheng Yang,
Fenghua Wang,
Xiaodong Sun
Publication year - 2019
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.19-27493
Subject(s) - choroidal neovascularization , macular degeneration , macrophage polarization , angiogenesis , macrophage migration inhibitory factor , retinopathy of prematurity , small interfering rna , macrophage , gene knockdown , cancer research , vascular endothelial growth factor a , medicine , biology , immunology , vascular endothelial growth factor , ophthalmology , transfection , in vitro , apoptosis , cytokine , genetics , cell culture , pregnancy , vegf receptors , gestational age
Choroidal neovascularization (CNV) is the principal pathological factor contributing to blindness in neovascular age-related macular degeneration (nAMD). Infiltration of M2 macrophage is thought to contribute to CNV progress, although the way that regulates its differentiation remains unclear. Here, we investigate the role of CHI3L1 in M2 differentiation and angiogenesis in CNV.