Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure | Zendy

YuChen Fan | Zendy; Li Guo | Zendy; Jiahong Wei | Zendy; Junzhao Chen | Zendy; Hao Sun | Zendy; Tao Guo | Zendy

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Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure

Author(s) -

YuChen Fan,

Li Guo,

Jiahong Wei,

Junzhao Chen,

Hao Sun,

Tao Guo

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-26585

Subject(s) - salidroside , trabecular meshwork , immunocytochemistry , extracellular matrix , fibronectin , chemistry , western blot , extracellular , intraocular pressure , blot , rhodiola , microbiology and biotechnology , pharmacology , endocrinology , medicine , biology , biochemistry , ophthalmology , gene

Excessive accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) reduces aqueous humor outflow, which likely contributes to elevation of IOP in primary open-angle glaucoma (POAG). Salidroside, a phenolic glycoside isolated from Rhodiola rosea is reported to prevent profibrotic responses by inhibiting Smad signaling pathway activated by TGF-β in liver, lung, and kidney tissues. We tested if salidroside can (1) inhibit TGF-β2-induced ECM expression in cultured human TM cells, and (2) lower TGF-β2-induced ocular hypertension in the mouse.

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