Open AccessMouse Cones Adapt Fast, Rods Slowly In Vivo
Author(s) -
Anneka Joachimsthaler,
Jan Kremers
Publication year - 2019
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.18-26356
Subject(s) - photopic vision , adaptation (eye) , luminance , contrast (vision) , visual phototransduction , electroretinography , erg , optics , rod , biophysics , physics , chemistry , anatomy , biology , retina , medicine , pathology , alternative medicine
To study rod- and cone-driven adaptation dynamics separately, we used the silent substitution technique to selectively stimulate rods or cones in the Opn1lwLIAIS (LIAIS) mouse, in which the native M-cone pigment is replaced by a human L-cone pigment (L*).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom