Apolipoprotein A-I Mimetic Peptide L-4F Removes Bruch's Membrane Lipids in Aged Nonhuman Primates | Zendy

Martin Rudolf | Zendy; Christine A. Curcio | Zendy; Ursula SchlötzerSchrehardt | Zendy; Armin Mir Mohi Sefat | Zendy; Aysegül Tura | Zendy; Zouhair Aherrahrou | Zendy; Max Brinkmann | Zendy; Salvatore Grisanti | Zendy; Yoko Miura | Zendy; Mahdy Ranjbar | Zendy

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Apolipoprotein A-I Mimetic Peptide L-4F Removes Bruch's Membrane Lipids in Aged Nonhuman Primates

Author(s) -

Martin Rudolf,

Christine A. Curcio,

Ursula SchlötzerSchrehardt,

Armin Mir Mohi Sefat,

Aysegül Tura,

Zouhair Aherrahrou,

Max Brinkmann,

Salvatore Grisanti,

Yoko Miura,

Mahdy Ranjbar

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25786

Subject(s) - bruch's membrane , drusen , macular degeneration , retinal pigment epithelium , retinal , ophthalmology , pathology , chemistry , medicine , biology

Multiple evidence lines support Bruch's membrane lipid deposition as a major precursor of soft drusen and age-related macular degeneration as including a potentially treatable atherosclerosis-like progression in the subretinal pigment epithelium (RPE)-basal lamina space. We evaluated the effect of anti-inflammatory, antiatherogenic peptide L-4F on Bruch's membrane of aged nonhuman primates in a dose-escalating study.

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