CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy | Zendy

Svenja Plöhn | Zendy; Bärbel Edelmann | Zendy; Lukasz Japtok | Zendy; Xingxuan He | Zendy; Matthias Hose | Zendy; Wiebke Hansen | Zendy; Edward H. Schuchman | Zendy; Anja Eckstein | Zendy; Utta BerchnerPfannschmidt | Zendy

Open Access

CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy

Author(s) -

Svenja Plöhn,

Bärbel Edelmann,

Lukasz Japtok,

Xingxuan He,

Matthias Hose,

Wiebke Hansen,

Edward H. Schuchman,

Anja Eckstein,

Utta BerchnerPfannschmidt

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25466

Subject(s) - sphingosine , sphingosine 1 phosphate , lipid signaling , ceramide , chemistry , sphingosine kinase , cd40 , sphingolipid , cd154 , inflammation , microbiology and biotechnology , sphingosine kinase 1 , receptor , fibroblast , endocrinology , medicine , biology , biochemistry , cytotoxic t cell , apoptosis , in vitro

Graves' orbitopathy (GO) is an autoimmune orbital disorder associated with Graves' disease caused by thyrotropin receptor autoantibodies. Orbital fibroblasts (OFs) and CD40 play a key role in disease pathogenesis. The bioactive lipid sphingosine-1-phosphate (S1P) has been implicated in promoting adipogenesis, fibrosis, and inflammation in OFs. We investigated the role of CD40 signaling in inducing S1P activity in orbital inflammation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research