Open AccessCD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy
Author(s) -
Svenja Plöhn,
Bärbel Edelmann,
Lukasz Japtok,
Xingxing He,
Matthias Hose,
Wiebke Hansen,
Edward H. Schuchman,
Anja Eckstein,
Utta BerchnerPfannschmidt
Publication year - 2018
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.18-25466
Subject(s) - sphingosine , sphingosine 1 phosphate , lipid signaling , ceramide , chemistry , sphingosine kinase , cd40 , sphingolipid , cd154 , inflammation , microbiology and biotechnology , sphingosine kinase 1 , receptor , fibroblast , endocrinology , medicine , biology , biochemistry , cytotoxic t cell , apoptosis , in vitro
Graves' orbitopathy (GO) is an autoimmune orbital disorder associated with Graves' disease caused by thyrotropin receptor autoantibodies. Orbital fibroblasts (OFs) and CD40 play a key role in disease pathogenesis. The bioactive lipid sphingosine-1-phosphate (S1P) has been implicated in promoting adipogenesis, fibrosis, and inflammation in OFs. We investigated the role of CD40 signaling in inducing S1P activity in orbital inflammation.