Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts | Zendy

Sun Woong Kim | Zendy; Hye-In Kim | Zendy; Bikash Thapa | Zendy; Selikem Abla Nuwormegbe | Zendy; Keunwook Lee | Zendy

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Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Author(s) -

Sun Woong Kim,

Hye-In Kim,

Bikash Thapa,

Selikem Abla Nuwormegbe,

Keunwook Lee

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25376

Subject(s) - mtorc2 , pi3k/akt/mtor pathway , mtorc1 , myofibroblast , protein kinase b , gene knockdown , microbiology and biotechnology , cancer research , chemistry , signal transduction , small interfering rna , biology , fibrosis , medicine , transfection , biochemistry , apoptosis , gene

Profibrotic activation is essential for pterygium development. In this study, we investigated the role of the mechanistic target of rapamycin (mTOR) in regulating TGF-β1-induced myofibroblastic responses in human pterygium fibroblasts (HPFs) and elucidated the relative contributions of mTOR signaling components.

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