Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice | Zendy

Helen Michael | Zendy; Cari GraffCherry | Zendy; Sung Chin | Zendy; Corinne Rauck | Zendy; Amelework D. Habtemichael | Zendy; Patricia Bunda | Zendy; Tunde Smith | Zendy; Maria M Campos | Zendy; Kapil Bharti | Zendy; Heinz Arnheiter | Zendy; Glenn Merlino | Zendy; ChiPing Day | Zendy

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Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

Author(s) -

Helen Michael,

Cari GraffCherry,

Sung Chin,

Corinne Rauck,

Amelework D. Habtemichael,

Patricia Bunda,

Tunde Smith,

Maria M Campos,

Kapil Bharti,

Heinz Arnheiter,

Glenn Merlino,

ChiPing Day

Publication year - 2018

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-25186

Subject(s) - microphthalmia associated transcription factor , ectopic expression , microphthalmia , biology , retinal pigment epithelium , retinal , microbiology and biotechnology , transcription factor , genetics , gene , biochemistry

Complete deficiency of microphthalmia transcription factor (MITF) in Mitfmi-vga9/mi-vga9 mice is associated with microphthalmia, retinal dysplasia, and albinism. We investigated the ability of dopachrome tautomerase (DCT) promoter-mediated inducible ectopic expression of Mitf-M to rescue these phenotypic abnormalities.

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