Altered Signaling Pathways in Aniridia-Related Keratopathy
Author(s) -
André Vicente,
Berit Byström,
Fátima Pedrosa Domellöf
Publication year - 2018
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.18-25175
Subject(s) - wnt signaling pathway , cyclopamine , gli1 , pax6 , hes1 , pi3k/akt/mtor pathway , aniridia , transplantation , hypohidrotic ectodermal dysplasia , biology , cancer research , corneal epithelium , hedgehog signaling pathway , pathology , medicine , signal transduction , microbiology and biotechnology , epithelium , notch signaling pathway , ectodermal dysplasia , transcription factor , biochemistry , genetics , gene
To study the Notch1, Wnt/beta-catenin, sonic hedgehog (SHH), and mammalian target of rapamycin (mTOR) cell signaling pathways in naïve and surgically treated corneas of aniridia cases with advanced aniridia-related keratopathy (ARK).
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