Open AccessChronic Intermittent Hypoxia Alters Rat Ophthalmic Artery Reactivity Through Oxidative Stress, Endothelin and Endothelium-Derived Hyperpolarizing Pathways
Author(s) -
Marielle Mentek,
Jessica Morand,
Marie Baldazza,
Gilles Faury,
Florent Aptel,
Jean Pépin,
Diane GodinRibuot,
Christophe Chiquet
Publication year - 2018
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.18-25151
Subject(s) - nitric oxide , nitric oxide synthase , oxidative stress , endocrinology , medicine , endothelin 1 , endothelin receptor , hypoxia (environmental) , obstructive sleep apnea , endothelium , chemistry , anesthesia , receptor , oxygen , organic chemistry
Obstructive sleep apnea recently has been associated with a higher frequency of ischemic optic neuropathies. Intermittent hypoxia (IH) has been proposed as a major component of obstructive sleep apnea cardiovascular consequences. However, there currently are no pathophysiologic data regarding the effect of IH on the ocular vascular system. Thus, we assessed the impact of chronic IH exposure on the morphology and vascular reactivity of the rat ophthalmic artery (OA).